Search results for " TLR-4 mediated signaling pathway"

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Can the TLR-4-mediated signaling pathway be "a key inflammatory promoter for sporadic TAA"?

2014

Thoracic aorta shows with advancing age various changes and a progressive deterioration in structure and function. As a result, vascular remodeling (VR) and medial degeneration (MD) occur as pathological entities responsible principally for the sporadic TAA onset. Little is known about their genetic, molecular, and cellular mechanisms. Recent evidence is proposing the strong role of a chronic immune/inflammatory process in their evocation and progression. Thus, we evaluated the potential role of Toll like receptor- (TLR-) 4-mediated signaling pathway and its polymorphisms in sporadic TAA. Genetic, immunohistochemical, and biochemical analyses were assessed. Interestingly, the rs4986790 TLR4…

MaleArticle SubjectGenotypeImmunologyAortic DiseasesSettore MED/41 - AnestesiologiaSingle-nucleotide polymorphismAorta ThoracicSettore MED/08 - Anatomia PatologicaBiologyPolymorphism Single NucleotideImmune systemPolymorphism (computer science)Genotypelcsh:PathologySettore MED/05 - Patologia ClinicaHumansGenetic Predisposition to DiseaseAgedToll-like receptorPolymorphism GeneticSettore MED/23 - Chirurgia CardiacaCell BiologyMiddle AgedPhenotypeImmunohistochemistryToll-Like Receptor 4medial degeneration sporadic thoracic aortic aneurysm TLR-4 mediated signaling pathway rs4986790 TLR4 polymorphism translation of genetic immunohistochemical and biochemical data clinical practiceImmunologyTLR4Matrix Metalloproteinase 2FemaleSignal transductionlcsh:RB1-214Research ArticleSignal Transduction
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